HepatoSar


HepatoSar is a marine compound of natural origin combined with artichoke extract, which contributes to stimulating hepatobiliary function and the digestion of fats, thus helping to protect the liver and gallbladder.

Benefits and Indications


R

Hepatobiliary Function

Stimulates hepatobiliary function.

Gallstones

Reduces the risk of gallstone formation.

Benefits of cynarine

The health that comes from the sea

Fats

Improves the digestion of fats.

Cholesterol

Normalizes the plasma levels of transaminases, cholesterol and triglycerides.


Recommended for:

  • boosting hepatobiliary function.
  • improving and facilitating digestive function.
  • improving gallbladder function.
  • forestalling the risk of gallstone formation.
  • improving the digestion of fats, and preventing slow, heavy digestions.
  • normalizing the plasmatic activity of hepatic transaminases (GOT, GPT and GGT).
  • normalizing the plasma levels of cholesterol and triglycerides.

- Lipoprotein Complex of Marine Origin -

HepatoSar is a food supplement of marine origin combined with artichoke (Cynara scolymus L.) extract, which contributes to normalizing hepatobiliary function and to improving the digestion of fats. It contains high biological value marine proteins, essential fatty acids, vitamins and minerals.


- Benefits of Cynarine -

Cynarine is the most noteworthy active ingredient of the artichoke, and is considered a medicinal foodstuff due to its beneficial effect on the organism, derived from its condition as a stimulant of bile secretion (choleretic effect). Cynarine is present in artichoke leaves and has a beneficial effect on the control of gallstones, helps control cholesterol levels and improves gallbladder function.

Scientific publications

HepatoSar decreases the activity of the liver enzyme GOT

HepatoSar-grafica-1
In 32 patients supplemented with a daily dose of 750 mg of HepatoSar for one month, a reduction in the activity of the hepatic enzyme GOT was observed.

HepatoSar decreases the activity of the liver enzyme GPT

HepatoSar-grafica-2
En 41 pacientes complementados con una dosis de 750 mg/día de HepatoSar durante 1 mes se observó una disminución de la actividad de la enzima hepática GPT.
In 41 patients supplemented with a daily dose of 750 mg of HepatoSar for one month, a reduction in the activity of the hepatic enzyme GPT was observed.

HepatoSar decreases the activity of the liver enzyme GGT

HepatoSar-grafica-3
En 45 pacientes complementados con una dosis de 750 mg/día de HepatoSar durante 1 mes se observó una disminución de la actividad de la enzima hepática GGT.
In 45 patients supplemented with a daily dose of 750 mg of HepatoSar for one month, a reduction in the activity of the hepatic enzyme GGT was observed.

Bibliography

1. Ackman RG. Structural Homogeneity in Unsaturated Fatty Acids of Marine Lipids. Lombardi VRM and Cacabelos R. E-SAR-94010®: a marine fish extract obtained by advanced biotechnological methods. Drugs of the Future 1999, 24(2): 167-176.
2. Lombardi VRM, Cagiao A, Fernández-Novoa L, Álvarez XA, Corzo MD, Zas R, Sampedro C and Cacabelos R. Short term food supplementation effects of a fish derived extract on the immunological status of pregnant rats and their sucking pups. Nutrition Research 2001, 21: 1425-1434.
3. Kris-Etherton PM, Harris WS, Appel LJ. Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease. Circulation 2002,106: 2747-2757.
4. Speroni E, Cervellati R, Govoni P, Guizzardi S, Renzulli C, Guerra MC. Efficacy of different Cynara scolymus preparations on liver complaints. J Ethnopharmacol 2003, 86(2-3):203-11.
5. Cacabelos R, Vallejo AI, Lombardi VRM, Fernández-Novoa L and Pichel V. E-SAR-94010®: a pleiotropic lipoprotein compound with powerful anti-atheromatous and lipid lowering effects. CNS Drug Reviews 2004 (summer), vol. 10, number 2.
6. De Leonardis A, Macciola V. A study on the lipid fraction of Adriatic sardine filets (Sardina pilchardus). Nahrung 2004, 48(3):209-12.
7. Huang TL, Zandi PP, Tucker KL, Fitzpatrick AL, Kuller LH, Fried LP. Benefits of fatty fish on dementia risk are stronger for those without APOE ε4. Neurology 2005, 65, 1409-1414.
8. Cacabelos R. Role of nutrition in the prevention of Alzheimer´s disease. Aging Health 2005, 1: 359-362.
9. Cacabelos R. Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer’s disease. Future Medicine. Aging Health 2005, 1(2): 303-348.
10. Nomikosa T, Karantonisb HC, Skarvelisc C, Demopoulosb CA, Zabetakisc I. Antiatherogenic properties of lipid fractions of raw and fried fish. Food Chemistry 2006, 96 (1): 29–35.
11. Cacabelos R. Application of Nutrigenomics to Alzheimer´s Disease. Agro FOOD Industry hi-tech 2008, vol. 19 number 6 Nov/Dic.
12. Cacabelos R. Pharmacogenomics in Alzheimer´s disease. Methods Mol Biol 2008; 448: 213-357.
13. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C – a pilot study. Phytomedicine 2009, 16(9):801-4.
14. Cacabelos R, Fernández-Novoa L, Martínez-Bouza R, McKay A, Carril JC, Lombardi V, Corzo L, Carrera I, Tellado I, Nebril L, Alcaraz M, Rodríguez S, Casas A, Couceiro V and Álvarez A. Future Trends in the Pharmacogenomics of Brain Disorders and Dementia: Influence of APOE and CYP2D6 variants. Pharmaceuticals 2010, 3: 3040-3100.
15. Marin M, Polak T, Gaŝperlin L, Ẑendler B. Variations in the fatty acid composition and nutritional value of Adriatic sardine (Sardina pilchardus Walb.) through the fishing season. Acta argiculturae Slovenica 2010, 96 (2): 95–101.
16. De Caterina R. n–3 Fatty Acids in Cardiovascular Disease. N Engl J Med 2011, 364: 2439-2450.
17. Metwally NS, Kholeif TE, Ghanem KZ, Farrag AR, Ammar NM, Abdel-Hamid AH. The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats. Eur Rev Med Pharmacol Sci 2011, 15(12):1429-44.
18. Rondanelli M, Monteferrario F, Perna S, Faliva MA, Opizzi A. Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action. Monaldi Arch Chest Dis 2013, 80(1):17-26.
19. Kurt H, Toprak O, Bülbül E. The possible efficacy of artichoke in fluconazole related hepatotoxicity. Case Reports Hepatol 2014, 2014:697359.
20. Ruiz-Cano D, Pérez-Llamas F, Frutos MJ, Arnao MB, Espinosa C, López-Jiménez JÁ, Castillo J, Zamora S. Chemical and functional properties of the different by-products of artichoke (Cynara scolymus L.) from industrial canning processing. Food Chem 2014; 1,160:134-40.
21. Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr 2015, 102(1):115-22.
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Information and data sheet

Nutritional values per capsule
Nutritional data (per capsule)
Proteins 137 mg
Carbohydrates 130 mg
Lipids 35 mg
Energy value 1,38 kcal (5,8 kJ)
Warnings and Precautions
  • Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.
  • Do not exceed the stated dose.
  • Not to be taken by persons with biliary obstruction.
  • Not to be taken by persons with an allergy to any of the components of its formulation.
  • HepatoSar® must not be taken by persons with phenylketonuria. Phenylketonuria is a hereditary metabolic disorder characterized by the deficiency of an enzyme, phenylalanine hydroxylase, required for the conversion of phenylalanine into other substances required by the organism. Phenylalanine is an amino acid, a basic component of proteins, and is therefore present in most foods.
  • It is not indicated for use during pregnancy and lactation without medical supervision.
  • Keep out of the reach of children.
Presentation
  • Boxes of 30 hard gelatin capsules.
  • Content per capsule:
    – 200 mg of lyophilized E-SAR-94010® extract
    – 150 mg Artichoke extract 5%
Preservation

Preservation

Directions
  • 3 capsules/day with meals.

Ask your physician or pharmacist about the health benefits of taking these nutrients as part of your daily diet.