LipoEsar


LipoEsar is a food supplement of marine origin which contributes to the maintenance of cardiovascular health and to normalizing cholesterol and triglyceride levels.

Benefits and Indications


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Cholesterol

LipoEsar balances the plasma levels of LDL- and HDL-cholesterol.

Glucose and uric acid

LipoEsar normalizes glucose and uric acid levels.

Normalizes fats in a natural way

The health that comes from the sea

Triglycerides

LipoEsar normalizes the plasma levels of triglycerides.

Hepatic enzymes

LipoEsar regulates the body’s transaminase levels, protecting hepatic function.


Recommended for:

  • contributing to the maintenance of cardiovascular health and the prevention of cerebrovascular accidents.
  • persons with cardiovascular problems: arterial hypertension, diabetes, cardiac arrhythmias.
  • persons with family history of cardiovascular diseases.
  • normalizing cholesterol and triglyceride levels.
  • increasing the intake of healthy omega-3, -6 and -9 fatty acids.

- Lipoprotein Complex of Marine Origin -

LipoEsar is a lipoprotein complex of marine origin extracted from the muscle of the marine species S. pilchardus (European sardine, Clupeidae family) by non-denaturing biotechnological processes which preserve the natural properties of the active ingredients.


- High Biological Value Marine Proteins -

LipoEsar is a nutraceutical of marine origin which contributes to the maintenance of the cardiovascular system function in optimal condition, regulating blood levels of cholesterol, triglycerides, glucose, uric acid and hepatic transaminases. LipoEsar is an ideal supplement to keep the cardiovascular system balanced and healthy, in addition to favoring hepatic function.

Studies and scientific publications

LipoEsar lowers the levels of total cholesterol, LDL-cholesterol and triglycerides in blood, and increases blood HDL-cholesterol levels.

In patients diagnosed with chronic dyslipidemia, LipoEsar® normalized the lipid levels in blood, showing that LipoEsar® favors cardiovascular health.
LipoEsar gráfica
In a group of 420 patients with chronic disruption of lipid levels in blood, the administration of LipoEsar® (E-SAR-94010®) as a supplement, at a dose of 750 mg/day, lowered blood total cholesterol levels by 10%, blood LDL-cholesterol levels by 8% and blood triglyceride levels by 29%, and increased blood HDL-cholesterol levels by 13%.

LipoEsar reduces the activity of the hepatic enzymes GOT, GPT and GGT.

lipoesar-gráfica2
In a group of 420 patients with chronic disruption of lipid levels in blood, the administration of LipoEsar® (E-SAR-94010®) as a supplement, at a dose of 750 mg/day, reduced the plasma activity of hepatic transaminases.

LipoEsar reduces the size of the atheroma plaque.

liposar ateroma
Oral administration of LipoEsar® at 1,500 mg/day for 3 months in 30 patients with chronic dyslipidemia, and who had developed atheroma plaques in the abdominal aorta, reduced the average size of the atheroma plaques on the wall of the aorta by 10%.

Bibliography

1. Ackman RG. Structural Homogeneity in Unsaturated Fatty Acids of Marine Lipids. A Review. J Fisheries Res Board Can 1964, 21(2): 247-254.
2. Lombardi VRM and Cacabelos R. E-SAR-94010®: a marine fish extract obtained by advanced biotechnological methods. Drugs of the Future 1999, 24(2): 167-176.
3. Lombardi VRM, Cagiao A, Fernández-Novoa L, Álvarez XA, Corzo MD, Zas R, Sampedro C and Cacabelos R. Short term food supplementation effects of a fish derived extract on the immunological status of pregnant rats and their sucking pups. Nutrition Research 2001, 21: 1425-1434.
4. Kris-Etherton PM, Harris WS, Appel LJ. Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease. Circulation 2002,106:2747-2757.
5. Cacabelos R, Vallejo AI, Lombardi VRM, Fernández-Novoa L and Pichel V. E-SAR-94010®: a pleiotropic lipoprotein compound with powerful anti-atheromatous and lipid lowering effects. CNS Drug Reviews 2004 (summer), vol. 10, number 2.
6. De Leonardis A, Macciola V. A study on the lipid fraction of Adriatic sardine filets (Sardina pilchardus). Nahrung 2004, 48(3):209-12.
7. Cacabelos R. Role of nutrition in the prevention of Alzheimer´s disease. Aging Health 2005, 1: 359-362.
8. Cacabelos R. Pharmacogenomics, nutrigenomics and therapeutic optimization in Alzheimer’s disease. Future Medicine. Aging Health 2005, 1(2): 303-348.
9. Huang TL, Zandi PP, Tucker KL, Fitzpatrick AL, Kuller LH, Fried LP. Benefits of fatty fish on dementia risk are stronger for those without APOE ε4. Neurology 2005, 65, 1409-1414.
10. Nomikosa T, Karantonisb HC, Skarvelisc C, Demopoulosb CA, Zabetakisc I. Antiatherogenic properties of lipid fractions of raw and fried fish. Food Chemistry 2006, 96 (1): 29–35.
11. Cacabelos R. Application of Nutrigenomics to Alzheimer´s Disease. Agro FOOD Industry hi-tech 2008, vol. 19 number 6 Nov/Dic.
12. Cacabelos R. Pharmacogenomics in Alzheimer´s disease. Methods Mol Biol 2008; 448: 213-357.
13. Cacabelos R, Fernández-Novoa L, Martínez-Bouza R, McKay A, Carril JC, Lombardi V, Corzo L, Carrera I, Tellado I, Nebril L, Alcaraz M, Rodríguez S, Casas A, CouceiroC V and Álvarez A. Future Trends in the Pharmacogenomics of Brain Disorders and Dementia: Influence of APOE and CYP2D6 variants. Pharmaceuticals 2010, 3: 3040-3100.
14. Marin M, Polak T, Gaŝperlin L, Ẑendler B. Variations in the fatty acid composition and nutritional value of Adriatic sardine (Sardina pilchardus Walb.) through the fishing season. Acta argiculturae Slovenica 2010, 96 (2): 95–101.
15. Bouderouaa K, Mourotb J, Benmehdi-Tabet-Aoullc F, Selselet-Attouc G. The Effects of Season and Site of Catch on Morphometric Characteristics, Mineral Content, and Fatty Acids of Sardines (Sardina pilchardus) Caught on the Algerian Coast. Journal of Aquatic Food Product Technology 2011, 20: 4, 412-420.
16. De Caterina R. n–3 Fatty Acids in Cardiovascular Disease. N Engl J Med 2011, 364: 2439-2450.
17. Chitra Som RS, Radhakrishnan CK. Seasonal variation in the fatty acid composition of Sardinella longiceps and Sardinella fimbriata: Implications for nutrition and pharmaceutical industry. Indian Journal of Geo Marine Sciences 2013, 42 (2): 206-210.
18. Nasopoulou C, Psani E, Sioriki E, Demopoulos CA, Zabetakis I. Evaluation of Sensory and in Vitro Cardio Protective Properties of Sardine (Sardina pilchardus): The Effect of Grilling and Brining. Food and Nutrition Sciences 2013, 4: 940-949.
19. Kim DH, Grodstein F, Rosner B, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Okereke OI. Seafood Types and Age-Related Cognitive Decline in the Women’s Health Study. J Gerontol A Biol Sci Med Sci 2013, 68(10): 1255–1262.
20. Smith GI, Julliand S, Reeds DN, Sinacore DR, Klein S, Mittendorfer B. Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults. Am J Clin Nutr 2015, 102(1):115-22.

Information and data sheet

Nutritional values per capsule
Nutritional data (per capsule)
Proteins 169 mg
Carbohydrates 4 mg
Lipids 50 mg
Energy value 1,14 kcal (4,79 kJ)
Warnings and Precautions
  • Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.
  • Not to be taken by persons with an allergy to any of the components of its formulation.
  • Do not exceed the stated dose.
  • Keep out of the reach of children.
  • LipoEsar® must not be taken by persons with phenylketonuria. Phenylketonuria is a hereditary metabolic disorder characterized by the deficiency of an enzyme, phenylalanine hydroxylase, required for the conversion of phenylalanine into other substances required by the organism. Phenylalanine is an amino acid, a basic component of proteins, and is therefore present in most foods.
Presentation
  • Boxes of 30 hard gelatin capsules.
  • Content per capsule:
    – 250 mg of lyophilized E-SAR-94010® extract
Preservation
  • Keep in a cool, dry place.
Directions
  • 3 capsules/day with meals.

Ask your physician or pharmacist about the health benefits of taking these nutrients as part of your daily diet.