AntiGan


AntiGan is a food supplement of marine origin that contributes to boosting the immune system and normal cell growth.

Benefits and Indications


Immunostimulant

AntiGan is recommended for the boosting of the immune system.

Bursts your inmune system

The health that comes from the sea

Regulation of cell growth

AntiGan contributes to the regulation of normal cell growth in the body.


Recommended for:

  • boosting the immune system.
  • modulating cell growth and differentiation.
  • contributing to a healthy diet and proper nutrition.

- Lipoprotein Complex of Marine Origin -

AntiGan is a lyophilized extract obtained from the muscle of the marine species C. conger (congridae family) by non-denaturing biotechnological processes which preserve the natural properties of the active ingredients.


- High Biological Value Marine Proteins -

AntiGan contains high biological value proteins, essential fatty acids, vitamins and minerals.

Studies and scientific publications

AntiGan (E-Congerine-10423) activates the body’s defense cells, principally the T-lymphocytes.

grafica-antigan-1
grafica-antigan2
Rats were subjected to a situation of immunosuppression by using hypothermia, and blood cells from the rats under study were stimulated in vitro with E-Congerine-10423®.
The following markers were studied:
CD4 +: T-helper cell marker
CD8 +: T-suppressor cell marker
CD25 +: activation and differentiation marker
CD28 +: activation marker

AntiGan (E-Congerine-10423) possesses cytotoxic activity in vitro against two (SW982 and SW872) of the four human tumoral lines used in our study.

grafica-antigan-3A series of in vitro toxicity experiments were performed, using different human tumoral lines treated with different concentrations of the E-Congerine-10423® compound. Four tumoral cell lines of human origin were used in the study: SW 982, synovial sarcoma; SW 872, liposarcoma; WM115, melanoma and CRL2871, lung adenocarcinoma.

Bibliography

1. Bean BA. The Conger Eel. Science 1902, 2; 15(383):715.
2. Muramoto K1, Kagawa D, Sato T, Ogawa T, Nishida Y, Kamiya H. Functional and structural characterization of multiple galectins from the skin mucus of conger eel, Conger myriaster. Comp Biochem Physiol B Biochem Mol Biol 1999, 123(1):33-45.
3. Shirai T, Mitsuyama C, Niwa Y, Matsui Y, Hotta H, Yamane T, Kamiya H, Ishii C, Ogawa T, Muramoto K. High-resolution structure of the conger eel galectin, congerin I, in lactose-liganded and ligand-free forms: emergence of a new structure class by accelerated evolution. Structure 1999; 15, 7(10):1223-33.
4. Suzuki Y, Tasumi S, Tsutsui S, Okamoto M, Suetake H. Molecular diversity of skin mucus lectins in fish. Comp Biochem Physiol B Biochem Mol Biol 2003, 136(4): 723-30.
5. Lombardi VR M, Pereira J, Etcheverría I, Fernández-Novoa L, Seoane S and Cacabelos R. Improvement of immune function by means of Conger conger extract in an in vivo rat model of cold stress. Food and Agricultural Immunology 2006, 17(1-4): 115-127.
6. Ogawa T1, Shirai T, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Muramoto K. The speciation of conger eel galectins by rapid adaptive evolution. Glycoconj J 2004, 19(7-9): 451-8.
7. Nakamura O, Matsuoka H, Ogawa T, Muramoto K, Kamiya H, Watanabe T. Opsonic effect of congerin, a mucosal galectin of the Japanese conger, Conger myriaster (Brevoort). Fish Shellfish Immunol 2006, 20(3):433-5.
8. Nakamura O, Inaga Y, Suzuki S, Tsutsui S, Muramoto K, Kamiya H, Watanabe T. Possible immune functions of congerin, a mucosal galectin, in the intestinal lumen of Japanese conger eel. Fish Shellfish Immunol 2007, 23(3): 683-92.
9. Nakamura O, Watanabe M, Ogawa T, Muramoto K, Ogawa K, Tsutsui S, Kamiya H. Galectins in the abdominal cavity of the conger eel Conger myriaster participate in the cellular encapsulation of parasitic nematodes by host cells. Fish Shellfish Immunol 2012, 33(4): 780-7.
10. Kwak CH, Lee SH, Lee SK, Ha SH, Suh SJ, Kwon KM, Chung TW, Ha KT, Chang YC, Lee YC, Kim DS, Chang HW, Kim CH. Induction of Apoptosis and Antitumor Activity of Eel Skin Mucus, Containing Lactose-Binding Molecules, on Human Leukemic K562 Cells. Mar Drugs 2015 19, 13(6):3936-49.
11. Conger conger, Sea Eel. Encyclopedia of Life. Available from http://www.eol.org.
12. Ogawa T1, Shirai T, Shionyu-Mitsuyama C, Yamane T, Kamiya H, Muramoto K. The speciation of conger eel galectins by rapid adaptive evolution. Glycoconj J 2004, 19(7-9): 451-8.
13. Nakamura O, Matsuoka H, Ogawa T, Muramoto K, Kamiya H, Watanabe T. Opsonic effect of congerin, a mucosal galectin of the Japanese conger, Conger myriaster (Brevoort). Fish Shellfish Immunol 2006, 20(3):433-5.
14. Nakamura O, Inaga Y, Suzuki S, Tsutsui S, Muramoto K, Kamiya H, Watanabe T. Possible immune functions of congerin, a mucosal galectin, in the intestinal lumen of Japanese conger eel. Fish Shellfish Immunol 2007, 23(3): 683-92.
15. Nakamura O, Watanabe M, Ogawa T, Muramoto K, Ogawa K, Tsutsui S, Kamiya H. Galectins in the abdominal cavity of the conger eel Conger myriaster participate in the cellular encapsulation of parasitic nematodes by host cells. Fish Shellfish Immunol 2012, 33(4): 780-7.
16. Kwak CH, Lee SH, Lee SK, Ha SH, Suh SJ, Kwon KM, Chung TW, Ha KT, Chang YC, Lee YC, Kim DS, Chang HW, Kim CH. Induction of Apoptosis and Antitumor Activity of Eel Skin Mucus, Containing Lactose-Binding Molecules, on Human Leukemic K562 Cells. Mar Drugs 2015 19, 13(6):3936-49.
17. Conger conger, Sea Eel. Encyclopedia of Life. Available from http://www.eol.org.

Information and data sheet

Nutritional values per capsule
Nutritional data (per capsule)
Proteins 200 mg
Carbohydrates 4 mg
Lipids 4 mg
Energy value 0,85 kcal (3,57 kJ)
Warnings and Precautions
  • Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle.
  • Not to be taken by persons with an allergy to any of the components of its formulation.
  • Do not exceed the stated dose.
  • AntiGan® must not be taken by persons with phenylketonuria. Phenylketonuria is a hereditary metabolic disorder characterized by the deficiency of an enzyme, phenylalanine hydroxylase, required for the conversion of phenylalanine into other substances required by the organism. Phenylalanine is an amino acid, a basic component of proteins, and is therefore present in most foods.
  • Keep out of the reach of children.
Presentation
  • Boxes of 30 hard gelatin capsules.
  • Content per capsule:
    – 250 mg of lyophilized E-Congerine-10423® extract.
Preservation
  • Keep in a cool, dry place.
Directions
  • 3 capsules/day with meals.

Ask your physician or pharmacist about the health benefits of taking these nutrients as part of your daily diet.